About CMC

Our laboratory is interested in cardiac gene regulatory mechanisms by transcription factors and microRNAs that control pathological cardiac remodeling, an early step towards heart failure. Chronic heart failure is a progressive disorder of the heart muscle that affects all vital organs, ultimately resulting in loss in quality of life. The most important causes of heart failure are chronic hypertension and myocardial infarction.

We study all three major cell types of the heart: cardiac muscle cells, fibroblasts and endothelial cells which express distinct sets of genes controlled by different combinations of extracellular signals, transcription factors and non-coding RNA species. We study these models to understand how programs of cellular differentiation and morphogenesis are affected in the processes leading to severe heart disease.

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Career

Interested in working in our laboratory?
Please send an email to: vacancies@cmcardio.nl or fill in the contactform

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Our latest publications

De Bortoli M, Calore C, Lorenzon A, Calore M, Poloni G, Mazzotti E, Rigato I, Marra MP, Melacini P, Iliceto S, Thiene G, Basso C, Daliento L, Corrado D, Rampazzo A, Bauce B. Co-inheritance of mutations associated with arrhythmogenic cardiomyopathy and hypertrophic cardiomyopathy. Eur J Hum Genet. 2017. doi: 10.1038/ejhg.2017.109.

D\'Souza A, Pearman CM, Wang Y, Nakao S, Logantha SJR, Cox C, Bennett HJ, Zhang Y, Johnsen AB, Linscheid N, Poulsen PC, Elliott J, Coulson J, McPhee JS, Robertson AC, da Costa Martins PA, Kitmitto A, Wisloff U, Cartwright EJ, Monfredi O, Lundby A, Dobrzynski H, Oceandy D, Morris GM, Boyett MR. Targeting miR-423-5p Reverses Exercise Training-Induced HCN4 Channel Remodeling and Sinus Bradycardia. Circ Res. 2017. doi: 10.1161/CIRCRESAHA.117.311607