About CMC

Our laboratory is interested in cardiac gene regulatory mechanisms by transcription factors and microRNAs that control pathological cardiac remodeling, an early step towards heart failure. Chronic heart failure is a progressive disorder of the heart muscle that affects all vital organs, ultimately resulting in loss in quality of life. The most important causes of heart failure are chronic hypertension and myocardial infarction.

We study all three major cell types of the heart: cardiac muscle cells, fibroblasts and endothelial cells which express distinct sets of genes controlled by different combinations of extracellular signals, transcription factors and non-coding RNA species. We study these models to understand how programs of cellular differentiation and morphogenesis are affected in the processes leading to severe heart disease.

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Career

Interested in working in our laboratory?
Please send an email to: vacancies@cmcardio.nl or fill in the contactform

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Our latest publications

Duygu B, Poels EM, Juni R, Bitsch N, Ottaviani L, Olieslagers S, De Windt LJ, da Costa Martins PA. miR-199b-5p is a regulator of left ventricular remodeling following myocardial infarction. Non-coding RNA Research. 2017;2:18-26.

Zucker IH, Lindsey ML, Delmar M, De Windt LJ, Des Rosiers C, Diz DI, Hester RL, Jones SP, Kanagy NL, Kitakaze M, Liao R, Lopaschuk GD, Patel KP, Recchia FA, Sadoshima J, Shah AM, Ungvari ZI, Benjamin IJ, Blaustein MP, Charkoudian N, Efimov IR, Gutterman DD, Kass DA, Liao Y, O\'Leary DS, Ripplinger CM, Wolin MS. Why Publish in the American Journal of Physiology-Heart and Circulatory Physiology? Am J Physiol Heart Circ Physiol. 2017 doi: 10.1152/ajpheart.00329.2017