Our laboratory is interested in cardiac gene regulatory mechanisms by transcription factors and microRNAs that control pathological cardiac remodeling, an early step towards heart failure. Chronic heart failure is a progressive disorder of the heart muscle that affects all vital organs, ultimately resulting in loss in quality of life. The most important causes of heart failure are chronic hypertension and myocardial infarction.
We study all three major cell types of the heart: cardiac muscle cells, fibroblasts and endothelial cells which express distinct sets of genes controlled by different combinations of extracellular signals, transcription factors and non-coding RNA species. We study these models to understand how programs of cellular differentiation and morphogenesis are affected in the processes leading to severe heart disease.
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